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IMPC 2021 - PROGRAMME

SCIENTIFIC PROGRAMME

Download the Scientific Programme HERE

Day 1 (23^rd September)
Day 2 (24^thSeptember)

14:00 - 14:10: WELCOME - Radislav Sedláček and Steve Brown
(10 minutes)

14:10 - 14:50: KEYNOTE Mario Capecchi (Salt Lake City, USA)
(40 minutes) Mouse Genetics and Genomic Medicine

14:50 - 16:30: SESSION I - Delivering the challenges of genomic medicine – The role of mouse genetics
CHAIR: Radislav Sedláček

14:50 - 15:15: Chris Austin (Boston, USA)
(25 minutes) From mouse genetics to human genomics to translational medicine

15:15 - 15:40: Kym Boycott (Ottawa, Canada)
(25 minutes) Canada's experience linking rare disease gene discovery to mechanism

15:40 - 16:05: Rob Williams (Memphis, USA)
(25 minutes) How To Build Robust Platforms for Experimental Precision Medicine Using Mice and Rats—Members of the Supraprimate
Superorder

16:05 - 16:30 Steve Brown (Harwell, UK)
(25 minutes) International Mouse Phenotyping Consortium: the generation of a comprehensive catalogue of gene function for genomic
medicine

16:30 - 16:45 Break
(15 minutes) E-poster viewing in the virtual E-POSTER AREA
Charles River Laboratories and Tecniplast video viewing in the CORPORATE PARTNERS’ VIDEO SHOWCASE

16:45 – 18:50: GENES, PHYSIOLOGY, AND DISEASE
                           SESSION II: Big data and mouse genetics
                           Approaches to the analysis, integration, and application of data on gene function
                           CHAIR: Colin Fletcher

16:45 – 17:10: Tudor Oprea (Albuquerque, USA)
(25 minutes) Illuminating the Rare Disease Proteome

17:10 – 17:35: Damian Smedley (London, UK)
(25 minutes) Application of IMPC data to rare disease diagnostics and discovery

17:35 – 18:00: Daria Julkowska (Paris, France)
(25 minutes) The European Joint Programme on Rare Diseases – the power of multistakeholder collaboration for the benefit of rare diseases patients

18:00 – 18:25: Malte Spielmann (Berlin/Lübeck, Germany)
(25 minutes) Single cell “whole embryo” phenotyping of developmental disorders

18:25 – 18:45: Henrik Westerberg (Harwell, UK)
(20 minutes) Exploring the IMPC embryo pipeline phenoscape with automatically annotated abnormal organ volumes

18:45-19:35: Break
(50 minutes) E-poster viewing in the virtual E-POSTER AREA
Charles River Laboratories and Tecniplast video viewing in the CORPORATE PARTNERS’ VIDEO SHOWCASE

19:35 - 20:20: SESSION III: Essential genes in mammals
                         Essential genes in mouse and humans and the power of developmental analyses of
                         essential genes and haploessential genes in the mouse for the identification of disease genes
                         CHAIR:Mary Dickinson

19:35 - 19:50: Evangelia Petsalaki (Cambridge, UK)
(15 minutes) Using CRISPR to dissect context-dependent cancer signaling networks

19:50 - 20:05: Ignatia Van Den Veyver (Houston, USA)
(15 minutes) Fetal precision medicine and the value of mouse models and transdisciplinary collaboration

20:05 - 20:20: Damaris Lorenzo (Chapel Hill, USA)
(15 minutes) Pathological mechanisms of the SPTBN1 syndrome

20:20 - 20:35: Pilar Cacheiro (London, UK)
(15 minutes) Early lethal genes in humans

20:35 – 20:50: Break
(15 minutes) E-poster viewing in the virtual E-POSTER AREA
Charles River Laboratories and Tecniplast video viewing in the CORPORATE PARTNERS’ VIDEO SHOWCASE

20:50 - 22:45: SESSION IV: Behaviour, sensory, and pain
                         A wide-ranging session discussing the power of mouse genetics to generate novel
                         translational insights into neurological pathways with wide implications across a
                         variety of neurological disease domains
                         CHAIR: Colin McKerlie

20:50 - 21:05: Erin Young (Kansas City, USA)
(15 minutes) Genetic Determinants of inflammatory hypersensitivity: From systems genetics to clinical translation

21:05 - 21:20: Jinchuan Xing (Piscataway, USA)
(15 minutes) The combination of multiple types of evidence to prioritize candidate genes for Tourette’s Disorder

21:20 - 21:35: Jason Lerch (Oxford, UK)
(15 minutes) Using mouse models to understand convergence and divergence in autism

21:35 - 21:50: Jacqui White (Bar Harbor, USA)
(15 minutes) Identifying genetic determinants of inflammatory pain in mice

21:50 - 22:05: Silvia Mandillo (Rome, Italy)
(15 minutes) The potential of home cage monitoring to screen mice for sleep disturbances

22:05 - 22:20: Elissa Chesler (Bar Harbor,USA)
(15 minutes) Network based prioritization of human GWAS candidates for schizophrenia using IMPC behavioral phenotypes

22:20 - 22:35: Sabine Hoelter-Koch (Munich, Germany)
(15 minutes) PREMOS: the European Brain Research Area Cluster on predictive model systems

22:35 – 22:45: Day 1 Wrap-up and Adjourn - Colin McKerlie
(10 minutes)

14:00 - 14:05: WELCOME - Martin Hrabě de Angelis
(05 minutes)

14:05 - 15:20: SESSION V: Use of mouse resources during the COVID-19 Pandemic
CHAIR: Ying Xu

14:05 - 14:30 Josef Penninger (Vancouver, Canada)
(25 minutes) ACE2 - from fly hearts to the heart of a pandemic

14:30 - 14:55: Paul McCray (Iowa City, USA)
(25 minutes) Mouse models of COVID-19 for studies of pathogenesis, preventions, and treatments

14:55 - 15:20: Je Kyung Seong (Seoul, Korea)
(25 minutes) Large scale Preclinical Test for COVID-19 infection

15:20-16:20: SESSION VI: Cardiovascular
                         Illuminating the role of mouse models and large-scale genetic screens to uncover
                         novel genes and pathways involved with cardiovascular disease from development to
                         the ageing adult
                         CHAIR Je Kyung Seong

15:20-15:35: Marc-Phillip Hitz (Kiel, Germany)
(15 minutes) Adamts19 and the use of an IMPC mouse model

15:35-15:50: Tara Rasmussen (Houston, USA)
(15 minutes) After the Pipeline: Identifying the Role of Glycogenin in Fetal Hearts

15:50-16:05: Xiaolei Xu (Rochester, USA)
(15 minutes) SORBS2 and arrhythmogenic cardiomyopathy

16:05-16:20: Nadine Spielmann (Munich, Germany)
(15 minutes) High-throughput mouse phenotyping in IMPC for the discovery of novel gene functions linked to human cardiovascular disease

16:20 – 16.35 Break
(15 minutes) E-poster viewing in the virtual E-POSTER AREA
Charles River Laboratories and Tecniplast video viewing in the CORPORATE PARTNERS’ VIDEO SHOWCASE

16:35 – 17:35: SESSION VII: Metabolism
                          Translational insights and developments from studies of novel mouse models of
                          metabolism metabolism from diabetes to bone
                          CHAIR: Martin Hrabě de Angelis

16:35 – 16:50: Zhihao Jia (Suzhou, China)
(15 minutes) PRMT5 regulates fatty acid metabolism and lipid droplet biogenesis

16:50 - 17:05: Oliver Fiehn (Davis, USA)
(15 minutes) Sex-dependent plasma metabolome and its association with IMPC mouse phenotypes

17:05 -17:20: Korbinian Riedhammer (Munich, Germany)
(15 minutes) FOXD2 as a candidate gene for a syndromic congenital disease of the kidney and urinary tract (CAKUT)

17:20 -17:35: Jan Rozman (Prague, Czech Republic)
(15 minutes) High-throughput mouse phenotyping in IMPC for the discovery of novel gene functions linked to human metabolic disease

17:35 - 18:25: Break
(50 minutes) E-poster viewing in the virtual E-POSTER AREA
Charles River Laboratories and Tecniplast video viewing in the CORPORATE PARTNERS’ VIDEO SHOWCASE

18:25 – 20:05 Session VIII: Mouse Genetics and Precision medicine
                          The wider translation impact of mouse genetics on genomic and precision medicine,
                          including the utility of bringing diverse mouse resources to bear for the analysis of disease systems
                          CHAIR: Kent Lloyd

18:25 - 18:50: Janet Rossant (Toronto, Canada)
(25 minutes) The ongoing role of mouse genetics in human precision health

18:50 - 19:15: Lucia Monaco (Milan, Italy)
(25 minutes) Fostering progression from basic research to accessible diagnosis and therapies for rare
diseases: the IRDiRC perspective

19:15 - 19:40: Hugo Bellen (Houston, USA)
(25 minutes) Strategies in flies to diagnose rare diseases and enabling preclinical studies

19:40 - 20:05: Yann Herault (Strasbourg, France)
(25 minutes) Investigating copy number variant diseases using mouse models from genetic dissection to preclinical proof of concept

20:05 - 20:20: Break
(15 minutes) E-poster viewing in the virtual E-POSTER AREA
Charles River Laboratories and Tecniplast video viewing in the CORPORATE PARTNERS’ VIDEO SHOWCASE

20:20 – 22:15 SESSION IX: Future challenges towards 2030
                          Discussion and presentations on challenges and priorities, including the dark genome,
                          non-coding variation, epigenetics, and the environment
                          CHAIR: Yann Herault

20:20 - 20:45: Yong Tian (Peking, China)
(25 minutes) Deciphering novel noncoding genes in mouse genome

20:45 - 21:10: Monica Justice (Toronto, Canada)
(25 minutes) Far To Go: Deciphering genomic communication and networks in mammals

21:10 - 21:35: Len Pennacchio (Los Angeles, USA)
(25 minutes) In Vivo Studies of Human Genome Function

21:35 - 22:00: Radislav Sedláček (Prague, Czech Republic)
(25 minutes) Beyond the null allele: from gene variants to gene networks and environmental impact

22:00 – 22:15: Day 2 Wrap-up, Concluding Remarks, and Closing the Conference
(25 minutes) Steve Brown, Yann Herault and Radislav Sedláček

SPEAKERS

Chris Austin Boston, USA
Hugo Bellen Houston, USA
Kym Boycott Ottawa, Canada
Steve Brown Harwell, UK
Pilar Cacheiro London, UK
Elissa Chesler Bar Harbor, USA
Yann Herault Strasbourg, France
Marc-Phillip Hitz Kiel, Germany
Sabine Hoelter-Koch Munich, Germany
Martin Hrabĕ de Angelis Munich, Germany
Zhihao Jia Suzhou, China
Daria Julkowska Paris, France
Monica Justice Toronto, Canada
Je Kyung Seong Seoul, Korea
Jason Lerch Oxford, UK
Damaris Lorenzo Chapel Hill, USA
Silvia Mandillo Rome, Italy
Paul McCray Iowa City, USA
Lucia Monaco Milan, Italy
Tudor Oprea Albuquerque, USA
Len Pennacchio Los Angeles, USA
Josef Penninger Vancouver, Canada
Evangelia Petsalaki Cambridge, UK

Tara Rasmussen Houston, USA
Korbinian Riedhammer Munich, Germany
Janet Rossant Toronto, Canada
Jan Rozman Prague, Czech Republic
Radislav Sedláček Prague, Czech Republic
Malte SpielmannBerlin/Lübeck, Germany
Damian Smedley London, UK
Nadine Spielmann Munich, Germany
Yong Tian Peking, China
Ignatia Van Den Veyver Houston, USA
Henrik Westerberg Harwell, UK
Jacqui White Bar Harbor, USA
Rob Williams Memphis, USA
Jinchuan Xing Piscataway, USA
Xiaolei Xu Rochester,USA
Erin Young Kansas City, USA